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Paxil cr contains exactly the same active ingredient as regular Paxil, (paroxetine hydrochloride) except that Paxil cr has an enteric coating that delays release until the drug has left the stomach.
The enteric coating of Paxil cr is a degradable polymeric matrix designed to control the dissolution rate of Paxil cr over a period of 4 to 5 hours. The inactive ingredients of Paxil cr consist of: hypromellose, polyvinylpyrrolidone, lactose monohydrate, magnesium stearate, colloidal silicon dioxide, glyceryl behenate, methacrylic acid copolymer type C, sodium lauryl sulfate, polysorbate 80, talc, triethyl citrate, and one or more of the following colorants: Yellow ferric oxide, red ferric oxide, D&C Red No. 30, D&C Yellow No.
6, D&C Yellow No. 10, FD&C Blue No. 2. The psychotropic drug Paxil cr was first approved in March 1999 as a treatment for major depressive disorder.
A few years later, Paxil cr was approved as a treatment for panic disorder.
And in early Sept. 2003, GlaxoSmithKline (the GSK) announced the U.S. Food and Drug Administration (FDA) approved Paxil cr as the first controlled-release medication for the treatment of premenstrual dysphoric disorder. Premenstrual dysphoric disorder (PMDD) is characterized by emotional symptoms including irritability, tension, and depressed mood as well as physical symptoms associated with the menstrual cycle.
PMDD, considered by some to be just a new name for premenstrual syndrome (PMS), consists of symptoms that commonly emerge in the second half of the menstrual cycle and subside when menstruation begins or shortly thereafter. The symptoms follow this pattern every month or almost every month. While I haven’t yet seen the data ‘proving’ paxil cr is ‘safe and effective’ for this brand new disease, the numbers touting its efficacy for panic and depression are readily available. Efficacy of Paxil CR The following numbers were obtained from the GSK’s own data.
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